Genomics and epigenomics of addiction

Recent progress in the genomics and epigenomics of addiction has contributed to improving our understanding this complex mental disorder's etiology, filling gap between genes, environment, behavior. We review behavioral genetic studies reporting gene environment interactions that explain polygenetic contribution resilience vulnerability develop addiction. discuss evidence polymorphic candidate genes confer susceptibility as well specific epigenetic marks contribute addictive-like A particular emphasis been devoted miRNA changes are considered potential biomarkers. The increasing knowledge about technology required alter expression may provide promising novel therapeutic tools. Finally, we give future directions for field's disentangling connection